Prof Thomas Ritter

PHD, DIP

Contact Details

Personal Professor
School of Medicine
Regenerative Medicine Institute
Biosciences
Dangan

T: Ext. 5329
E: thomas.ritter@nuigalway.ie
 
researcher

Biography

Prof Thomas Ritter, leader of research programme, was recruited by REMEDI as a lecturer in Gene Therapy Medicine and assumed his position in March 2005. Prof. Ritter has over 20 year experience in the field of gene therapy in organ transplantation. He obtained his Ph.D. degree in 1994 from the Max-Planck Research group of Immunology/Rheumatology at the University of Erlangen-Nuremberg, Germany where he worked on the molecular characterization of T cell receptors specific for human collagen type II. Having completed his Post-Doctoral Fellowship at Marseille, Center of Immunology in 1995, Prof. Ritter took up a faculty position at the prestigious Charité University Hospital in Berlin, Germany. He worked as a leader of the gene therapy programme in experimental transplantation in the Institute of Medical Immunology under the directorship of Prof. Dr. H.-D. Volk. His research focused on the development of efficient viral gene-transfer systems for application in transplantation medicine. Prof. Ritter was successful in obtaining funding from the German Research Foundation and the Ministry of Health and Research as well as from industry (Schering). His teaching duties in this position included lectures and courses in cellular and molecular immunology for biology and medical students. Prof. Ritter completed his 'Habilitation' (postdoctoral lecture qualification) in Immunology in 2002 followed by a promotion to assistant professor in 2003.
Since his appointment in 2005 Prof Ritter was successful in obtaining substantial funding from several funding agencies including Science Foundation of Ireland (SFI), Health Research Board (HRB), Irish Research Council (IRC) and the European Union FP7 programme totalling in approx. €4M in direct costs. He has published 80 original articles in peer-reviewed journals, 23 reviews, 1 editorial, 3 book chapters. Moreover I have given more than 30 invited lectures, seminars and oral presentations. He serves as a referee for many journals including American Journal of Transplantation, Biomaterials, Gene Therapy, Invest. Ophthal. Vis. Sci. (IOVS), Molecular Therapy, Stem Cells, Stem Cell Res & Ther., Transplantation, Transplant Immunology, Transplant International, BMC Ophthalmology. He also serves as grant assessor for the German Research Foundation (DFG), Wellcome Trust and Action Medical Research (UK) and NUI Galway, Millennium Funds, Minor project applications. He is a member of the German Society of Immunology (DFGI), Irish Society of Gene and Cell Therapy (ISGCT, founding member), the Association for Research in Vision and Ophthalmology (ARVO) and the American Society of Gene and Cell Therapy (ASGCT). Currently he is also the Chair of the Irish Society of Gene and Cell Therapy and has been appointed as Vice-Dean for Research for the College of Medicine at NUI Galway in Summer 2012. Prof Ritter is a founding member of a new non-profit organization called the European Cornea Research Association (ECRA), whose goals it is to promote cornea research in Europe, interlink current and future EU-funded cornea research in Europe, foster exchange between European cornea researchers and with the wider community and lobby for continued cornea research funding in Brussels. He is also a member of the management committee of a European Action on Cooperation in Science and Technology (COST) called AFACTT which was founded by the European Union in 2014. The aim of this Action is to build a network of European Centres involved in Cell-based Tolerance-inducing Therapies (CTT) that will synergise CTT efforts to maximise gain of knowledge and to fast-forward directed CTT development for treatment of AID, allergy and prevention of graft rejection.

Research Interests

Novel therapeutic approaches to improve corneal transplant survival by gene and cell therapy and insights into the mechanism of action
  • To investigate whether the immunomodulatory properties of mesenchymal stem cells can be utilised to improve corneal allograft survival
  • To understand the mechanism of PD-L1 mediated promotion of corneal allograft survival
To develop novel gene- and cell therapeutic approaches for the treatment of ocular surface injuries
To understand how changes in cell surface glycosylation modulate the tolerogenic potential of regulatory cells
To understand to role of extracellular vesicles secreted from mesenchymal stem cells in modulation of ocular surface injury
key words: Transplantation, Gene Therapy, Immunology, Mesenchymal Stem Cells, Immunomoduation, tolerogenic cells,

Peer Reviewed Journals

  Year Publication
(2016) 'Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells'
Ribeiro, A,Ritter, T,Griffin, M,Ceredig, R (2016) 'Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells'. Immunology Letters, 177 :38-46 [DOI] [Details]
(2016) 'Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation'
Murphy, N; Lynch, K; Lohan, P; Treacy, O; Ritter, T. (2016) 'Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation'. Current Opinion In Organ Transplantation, 21 (6):559-567 [DOI] [Details]
(2016) 'Corrigendum to: Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells [J. Immunol. Lett. 177 (2016) 38-46]'
Ribeiro A, Ritter T, Griffin M, Ceredig R (2016) 'Corrigendum to: Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells [J. Immunol. Lett. 177 (2016) 38-46]'. Immunology Letters, [DOI] [Details]
(2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'
Lohan, P,Treacy, O,Lynch, K,Barry, F,Murphy, M,Griffin, MD,Ritter, T,Ryan, AE (2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'. Osteoarthritis And Cartilage, 24 :521-533 [DOI] [Details]
(2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'
O'Malley, G; Heijltjes, M; Houston, AM; Rani, S; Ritter, T; Egan, LJ; Ryan, AE (2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'. Oncotarget, 7 (37):60752-60773 [DOI] [Details]
(2016) 'Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies'
Lord, P,Spiering, R,Aguillon, JC,Anderson, AE,Appel, S,Benitez-Ribas, D,ten Brinke, A,Broere, F,Cools, N,Cuturi, MC,Diboll, J,Geissler, EK,Giannoukakis, N,Gregori, S,van Ham, SM,Lattimer, S,Marshall, L,Harry, RA,Hutchinson, JA,Isaacs, JD,Joosten, I,van Kooten, C,de Cerio, ALD,Nikolic, T,Oral, HB,Sofronic-Milosavljevic, L,Ritter, T,Riquelme, P,Thomson, AW,Trucco, M,Vives-Pi, M,Martinez-Caceres, EM,Hilkens, CMU (2016) 'Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies'. Peerj, 4 [DOI] [ARAN Link] [Details]
(2016) 'The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing'
Rani, S,Ritter, T (2016) 'The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing'. Advanced Materials, 28 :5542-5552 [DOI] [Details]
(2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'
Farrell E;Fahy N;Ryan AE;Flatharta CO;O'Flynn L;Ritter T;Murphy JM; (2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'. Stem Cell Research & Therapy, 7 (1) [DOI] [Details]
(2015) 'Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint'
Fahy, N,Farrell, E,Ritter, T,Ryan, AE,Murphy, JM (2015) 'Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint'. Tissue Engineering Part B-Reviews, 21 :55-66 [DOI] [Details]
(2015) 'Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications'
Rani, S,Ryan, AE,Griffin, MD,Ritter, T (2015) 'Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications'. Molecular Therapy, 23 (5):812-823 [DOI] [Details]
(2014) 'TNF alpha and IL-1 beta influence the differentiation and migration of murine MSCs independently of the NF-kappa B pathway'
Sullivan, CB,Porter, RM,Evans, CH,Ritter, T,Shaw, G,Barry, F,Murphy, JM (2014) 'TNF alpha and IL-1 beta influence the differentiation and migration of murine MSCs independently of the NF-kappa B pathway'. Stem Cell Research & Therapy, 5 [DOI] [Details]
(2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'
Lohan P, Coleman CM, Murphy JM, Griffin MD, Ritter T, Ryan AE (2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'. Stem Cell Research & Therapy, 5 (4) [DOI] [Details]
(2014) 'Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation'
Treacy O, O'Flynn L, Ryan AE, Morcos M, Lohan P, Schu S, Wilk M, Fahy G, Griffin MD, Nosov M, Ritter T (2014) 'Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation'. American Journal Of Transplantation, 14 (9):2023-2036 [DOI] [Details]
(2014) 'Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation'
Ryan, AE; Lohan, P; O'Flynn, L; Treacy, O; Chen, X; Coleman, C; Shaw, G; Murphy, M; Barry, F; Griffin, MD; Ritter, T. (2014) 'Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation'. Molecular Therapy, [Details]
(2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'
Griffin, MD,Ryan, AE,Alagesan, S,Lohan, P,Treacy, O,Ritter, T (2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'. Immunology And Cell Biology, 91 :40-51 [DOI] [Details]
(2013) 'Gene Therapy Approaches to Prevent Corneal Graft Rejection: Where Do We Stand?'
Ritter, T,Wilk, M,Nosov, M (2013) 'Gene Therapy Approaches to Prevent Corneal Graft Rejection: Where Do We Stand?'. Ophthalmic Research, :135-140 [DOI] [Details]
(2013) 'Allogeneic Murine Mesenchymal Stem Cells: Migration to Inflamed Joints In Vivo and Amelioration of Collagen Induced Arthritis When Transduced to Express CTLA4Ig'
Sullivan C, Barry F, Ritter T, O'Flatharta C, Howard L, Shaw G, Anegon I, Murphy M (2013) 'Allogeneic Murine Mesenchymal Stem Cells: Migration to Inflamed Joints In Vivo and Amelioration of Collagen Induced Arthritis When Transduced to Express CTLA4Ig'. Stem Cells and Development, [DOI] [Details]
(2013) 'Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'
Griffin, MD,Elliman, SJ,Cahill, E,English, K,Ceredig, R,Ritter, T (2013) 'Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'. Stem Cells, 31 :2033-2041 [DOI] [Details]
(2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'
O'Flynn L, Treacy O, Ryan AE, Morcos M, Cregg M, Gerlach J, Joshi L, Nosov M, Ritter T (2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'. Molecular Therapy, 21 (11):2102-2112 [DOI] [ARAN Link] [Details]
(2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'
Treacy, O,Ryan, AE,Heinzl, T,O'Flynn, L,Cregg, M,Wilk, M,Odoardi, F,Lohan, P,O'Brien, T,Nosov, M,Ritter, T (2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'. Plos One, 7 [DOI] [ARAN Link] [Details]
(2012) 'Immunogenicity of allogeneic mesenchymal stem cells'
Schu, S,Nosov, M,O'Flynn, L,Shaw, G,Treacy, O,Barry, F,Murphy, M,O'Brien, T,Ritter, T (2012) 'Immunogenicity of allogeneic mesenchymal stem cells'. Journal Of Cellular And Molecular Medicine, 16 :2094-2103 [DOI] [ARAN Link] [Details]
(2012) 'Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival'
Nosov, M; Wilk, M; Morcos, M; Cregg, M; O'Flynn, L; Treacy, O; Ritter, T. (2012) 'Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival'. American Journal Of Transplantation, [Details]
(2011) 'Control of tumor necrosis factor-induced dendritic cell maturation and subsequent priming of T cells by hybrid-type N-glycans'
Schlickeiser, S., Stanjolivic, S., Appelt, C., Vogt, K., Vogel, S., Haase, S., Ritter, T., Volk, H.-D., Pleyer, U., Sawitzki, B. (2011) 'Control of tumor necrosis factor-induced dendritic cell maturation and subsequent priming of T cells by hybrid-type N-glycans'. J. Immunology, 186 (9):5201-5211 [DOI] [Details]
(2011) 'Mesenchymal stem cell effects on T-cell effector pathways'
Duffy MM, Ritter T, Ceredig R, Griffin MD (2011) 'Mesenchymal stem cell effects on T-cell effector pathways'. Stem Cell Research & Therapy, 2 (4) [DOI] [Details]
(2010) 'Genetically Modified Mesenchymal Stem Cells and Their Clinical Potential in Acute Cardiovascular Disease'
Griffin M, Greiser U, Barry FP, O'Brien T, Ritter T (2010) 'Genetically Modified Mesenchymal Stem Cells and Their Clinical Potential in Acute Cardiovascular Disease'. Discovery Medicine, 9 (46):219-223 [Details]
(2010) 'Immunological aspects of allogeneic mesenchymal stem cell therapies. Invited Review'
Griffin, M., Ritter, T., Mahon, B. (2010) 'Immunological aspects of allogeneic mesenchymal stem cell therapies. Invited Review'. Human Gene Therapy, :1641-1655 [Details]
(2010) 'Influence of combined treatment with rapamycin and cyclosporine A on corneal allograft survival in mice'
Stanjolivic, S., Schlickeiser, S., Appelt, C., Vogt, K., Schmitt-Knosalla, I., Haase, S., Ritter, T., Sawitzki, B. and U. Pleyer. (2010) 'Influence of combined treatment with rapamycin and cyclosporine A on corneal allograft survival in mice'. Graefes Arch Clin Exp Ophthalmol, 248 (10):1447-1456 [Details]
(2010) 'Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides'
Hoare, M,Greiser, U,Schu, S,Mashayekhi, K,Aydogan, E,Murphy, M,Barry, F,Ritter, T,O'Brien, T (2010) 'Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides'. Journal Of Gene Medicine, 12 :207-218 [DOI] [Details]
(2009) 'Corneal allograft endothelial cell replacement represents a reparative response to transplant injury'
Gong, NQ,Pleyer, U,Ritter, T,Knop, E,Chen, XP (2009) 'Corneal allograft endothelial cell replacement represents a reparative response to transplant injury'. Mol Vis, 15 :654-661 [Details]
(2009) 'Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord Without Differentiating into Neural Cells'
Rooney, GE,McMahon, SS,Ritter, T,Garcia, Y,Moran, C,Madigan, NN,Flugel, A,Dockery, P,O'Brien, T,Howard, L,Windebank, AJ,Barry, FP (2009) 'Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord Without Differentiating into Neural Cells'. Tissue Engineering Part A, 15 :3049-3059 [DOI] [ARAN Link] [Details]
(2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'
Kealy, B,Liew, A,McMahon, JM,Ritter, T,O'Doherty, A,Hoare, M,Greiser, U,Vaughan, EE,Maenz, M,O'Shea, C,Barry, F,O'Brien, T (2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'. Tissue Engineering Part C-Methods, 15 :223-231 [DOI] [Details]
(2009) 'Gene therapy in transplantation: Toward clinical trials'
Ritter, T,Nosov, M,Griffin, MD (2009) 'Gene therapy in transplantation: Toward clinical trials'. Current Opinion In Molecular Therapeutics, 11 :504-512 [Details]
(2009) 'Novel gene therapeutic strategies for the induction of tolerance in cornea transplantation'
Ritter, T,Pleyer, U (2009) 'Novel gene therapeutic strategies for the induction of tolerance in cornea transplantation'. Expert Review Of Clinical Immunology, 5 :749-764 [DOI] [Details]
(2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'
Murray, TVA,McMahon, JM,Howley, BA,Stanley, A,Ritter, T,Mohr, A,Zwacka, R,Fearnhead, HO (2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'. Journal Of Cell Science, 121 :3786-3793 [DOI] [Details]
(2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'
Rooney, GE,Moran, C,McMahon, SS,Ritter, T,Maenz, M,Flugel, A,Dockery, P,O'Brien, T,Howard, L,Windebank, AJ,Barry, FP (2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'. Tissue Engineering Part A, 14 :681-690 [DOI] [Details]
(2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'
Holohan, C,Szegezdi, E,Ritter, T,O'Brien, T,Samali, A (2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'. Journal Of Cellular And Molecular Medicine, 12 :591-606 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'
Reeve, JLV,Szegezdi, E,Logue, SE,Chonghaile, TN,O'Brien, T,Ritter, T,Samali, A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'. Journal Of Cellular And Molecular Medicine, 11 :509-520 [DOI] [Details]
(2007) 'The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival'
Fabian, D,Gong, N,Vogt, K,Volk, HD,Pleyer, U,Ritter, T (2007) 'The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival'. Graefes Archive For Clinical And Experimental Ophthalmology, 245 :1515-1521 [DOI] [Details]
(2007) 'Ex vivo gene transfer of viral interleukin-10 to BB rat islets: no protection after transplantation to diabetic BB rats'
Kuttler, B,Wanka, H,Kloting, N,Gerstmayer, B,Volk, HD,Sawitzki, B,Ritter, T (2007) 'Ex vivo gene transfer of viral interleukin-10 to BB rat islets: no protection after transplantation to diabetic BB rats'. Journal Of Cellular And Molecular Medicine, 11 :868-880 [DOI] [Details]
(2007) 'Effects of local and systemic viral interleukin-10 gene transfer on corneal allograft survival'
Gong, N,Pleyer, U,Volk, HD,Ritter, T (2007) 'Effects of local and systemic viral interleukin-10 gene transfer on corneal allograft survival'. Gene Therapy, 14 :484-490 [DOI] [Details]
(2007) 'Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival'
Gong, NQ,Pleyer, U,Vogt, K,Anegon, I,Flugel, A,Volk, HD,Ritter, T (2007) 'Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival'. Investigative Ophthalmology & Visual Science, 48 :1043-1052 [DOI] [Details]
(2007) 'Gene transfer of cyto-protective molecules in corneal endothelial cells and cultured corneas: Analysis of protective effects in vitro and in vivo'
Gong, N,Ecke, I,Mergler, S,Yang, J,Metzner, S,Schu, S,Volk, HD,Pleyer, U,Ritter, T (2007) 'Gene transfer of cyto-protective molecules in corneal endothelial cells and cultured corneas: Analysis of protective effects in vitro and in vivo'. Biochemical And Biophysical Research Communications, 357 :302-307 [DOI] [Details]
(2007) 'Viral Interleukin-10 Gene Transfer Prevents Liver Ischemia-Reperfusion Injury: Toll-Like Receptor-4 and Heme Oxygenase-1 Signaling in Innate and Adaptive Immunity'
Ke, B., Shen, X.-D., Tsuchihashi, S., Gao, F., Araujo, J.A., Busuttil, R.W., Ritter, T., Kupiec-Weglinski, J.W. (2007) 'Viral Interleukin-10 Gene Transfer Prevents Liver Ischemia-Reperfusion Injury: Toll-Like Receptor-4 and Heme Oxygenase-1 Signaling in Innate and Adaptive Immunity'. Hum Gene Ther, 18 (4):355-366 [Details]
(2007) 'Effects of Spirolactone on corneal allograft survival in the rat'
Otasevic, L., Gong, N., Ritter, T., Mergler, S., Pleyer, U. (2007) 'Effects of Spirolactone on corneal allograft survival in the rat'. Ophthalmic Res, 39 :325-329 [Details]
(2007) 'Influence of Inducible Co-stimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival'
Fabian, D., Gong, N., Vogt, K., Volk, H.-D., Pleyer, U., Ritter, T. (2007) 'Influence of Inducible Co-stimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival'. Graefes Arch Clin Exp Ophthalmol, 245 (10):1515-1521 [Details]
(2007) 'Heme oxygenase-1 inhibits T-cell dependent skin inflammation and differentiation and function of antigen presenting cells'
Listopad, J., Asadullah, K., Sievers, C. Ritter, T., Meisel, C., Sabat, R., Docke, W.-D. (2007) 'Heme oxygenase-1 inhibits T-cell dependent skin inflammation and differentiation and function of antigen presenting cells'. Exp Dermatol, 16 :661-670 [Details]
(2006) 'Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression'
Brock, P,Sparmann, G,Ritter, T,Jaster, R,Liebe, S,Emmrich, J (2006) 'Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression'. Journal Of Cellular And Molecular Medicine, 10 :884-895 [DOI] [Details]
(2006) 'Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion'
Zenclussen, M.L., Anegon, I., Bertoja, A.Z., Chauveau, C., Vogt, K., Gerlof, K., Sollwedel, A., Volk, H.D., Ritter, T., Zenclussen, A.C. (2006) 'Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion'. J Reprod Immunol, 69 (1):35-52 [Details]
(2006) 'Influence of local and systemic CTLA(4)lg gene transfer on corneal allograft survival'
Gong, NQ,Pleyer, U,Yang, J,Vogt, K,Hill, M,Anegon, I,Volk, HD,Ritter, T (2006) 'Influence of local and systemic CTLA(4)lg gene transfer on corneal allograft survival'. Journal Of Gene Medicine, 8 :459-467 [DOI] [Details]
(2005) 'Expression of TNF Inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis'
Trousdale, M.D., Zhu, Z., Stevenson, D., Schechter, J.E., Ritter, T., Mircheff, A. (2005) 'Expression of TNF Inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis'. J. Autoimmune Dis, 2 (1) [Details]
(2005) 'Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model'
Zenclussen, A., C., Gerlof, K., Zenclussen, M.L., Sollwedel, A., Bertoja, A.Z., Ritter, T., Kotsch, K., Leber, J., Volk, H.D (2005) 'Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model'. Am J Pathol, 166 (3):811-822 [Details]
(2005) 'The use of gene therapy tools in reproductive immunology research'
Zenclussen AC, Zenclussen ML, Ritter, T., Volk, H.-D. (2005) 'The use of gene therapy tools in reproductive immunology research'. Current Gene Therapy, 5 (5):459-466 [Details]
(2005) 'Effects of a selective steroid receptor agonist (SEGRA) on experimental keratoplasty'
Pleyer, U., Yang, J., Knapp, S., Schäcke H., Schmees N., Orlic, N., Otasevic, L., De Ruijter, M., Ritter, T., Keipert, S (2005) 'Effects of a selective steroid receptor agonist (SEGRA) on experimental keratoplasty'. Graefes Arch Clin Exp Ophthalmol, 243 :450-455 [Details]
(2005) 'Autoimmune CD4+ T cell memory: Life long persistence of encephalitogenic T cell clones in healthy immune repertoires'
Kawakami, N., Odoardi, F., Ziemssen, T., Bradl., M., Ritter, T., Neuhaus, O., Lassmann, H., Wekerle, H., Fluegel, A. (2005) 'Autoimmune CD4+ T cell memory: Life long persistence of encephalitogenic T cell clones in healthy immune repertoires'. J Immunol, 175 (1):69-81 [Details]
(2005) 'Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus'
Zenclussen, M.L., Anegon, I., Bertoja, A.Z., Chauveau, C., Vogt, K., Gerlof, K., Sollwedel, A., Volk, H.D., Ritter, T., Zenclussen, A.C. (2005) 'Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus'. Scand J Gastroenterology, 40 (9):1109-1117 [Details]
(2005) 'Gene therapy for the prevention of ischemia/reperfusion injury in transplantation. Invited review'
Ritter T., Kupiec-Weglinski JW. (2005) 'Gene therapy for the prevention of ischemia/reperfusion injury in transplantation. Invited review'. Current Gene Therapy, 5 (1):101-109 [Details]
(2005) 'Allo-specific T-cells encoding for viral IL-10 exert strong immunomodulatory effects in vitro but fail to prevent allogeneic graft rejection'
Brandt, C., Yang, J., Hammer, M., Schmitt-Knosalla, I., Siepert, A., Hammer, M.H., Vogt, K., Sawitzki, B., Lehmann, M. Volk, H-D, Ritter, T (2005) 'Allo-specific T-cells encoding for viral IL-10 exert strong immunomodulatory effects in vitro but fail to prevent allogeneic graft rejection'. Am J Transplant, 5 (2):268-281 [Details]
(2004) 'FTY720 prevents anti-CD4 induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model'
Pleyer, U., Yang, J., Knapp, S., Schäcke H., Schmees N., Orlic, N., Otasevic, L., De Ruijter, M., Ritter, T., Keipert, S. (2004) 'FTY720 prevents anti-CD4 induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model'. Am J Transplant, 4 (6):863-871 [Details]
(2004) 'Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation'
Aboul-Enein F, Bauer J, Klein M, Schubart A, Flugel A, Ritter T, Kawakami N, Siedler F, Linington C, Wekerle H, Lassmann H, Bradl M. (2004) 'Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation'. J Neuropathol Exp Neurol, 63 (12):1284-1296 [Details]
(2004) 'The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of experimental autoimmune encephalomyelitis'
Kawakami, N., Lassmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W.E.F., Ellwart, J.W., Bradl, M., Lassmann, H., Ransohoff, R.M., Volk, H.-D., Wekerle, H., Linington, C., Flügel, A. (2004) 'The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of experimental autoimmune encephalomyelitis'. J. Exp. Med, 199 (2):185-197 [Details]
(2004) 'Decline of surface MHC I by adenoviral gene transfer of anti-MHC I intrabodies in human endothelial cells - new perspectives for the generation of universal donor cells for tissue transplantation'
Beyer F, Doebis C, Busch A, Ritter T, Mhashilkar A, Marasco WM, Laube H, Volk HD, Seifert M (2004) 'Decline of surface MHC I by adenoviral gene transfer of anti-MHC I intrabodies in human endothelial cells - new perspectives for the generation of universal donor cells for tissue transplantation'. J Gene Med, 4 (6):616-623 [Details]
(2004) 'Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy'
Holm, P.S., Lage, H., Bergmann, S., Jurchott, K., Glockzin, G., Bernshausen, A., Mantwill, K., Ladhoff, A., Wichert, A., Mymryk, J.S., Ritter, T., Dietel, M., Gansbacher, B., Royer, H.D. (2004) 'Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy'. Cancer Res, 64 (1):322-328 [Details]
(2004) 'Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis'
Aboul-Enein F, Bauer J, Klein M, Schubart A, Flugel A, Ritter T, Kawakami N, Siedler F, Linington C, Wekerle H, Lassmann H, Bradl M. (2004) 'Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis'. Invest. Ophthal. Vis. Sci, 45 (5):1375-1381 [Details]
(2003) 'Gentherapie in der Transplantation: Experimentelle Ansätze zum Transfer anti-inflammatorischer und zytoprotektiver Gene zur Transplantaterhaltung'
Ritter, T., Volk, H.-D (2003) 'Gentherapie in der Transplantation: Experimentelle Ansätze zum Transfer anti-inflammatorischer und zytoprotektiver Gene zur Transplantaterhaltung'. Deutsche medizinische Wochenschrift (1946), 128 (33):1711-1714 [Details]
(2003) 'Efficiency of cytokine gene transfer in corneal endothelial cells and organ cultured corneas mediated by liposomal vehicles and recombinant adenovirus'
Holm, P.S., Lage, H., Bergmann, S., Jurchott, K., Glockzin, G., Bernshausen, A., Mantwill, K., Ladhoff, A., Wichert, A., Mymryk, J.S., Ritter, T., Dietel, M., Gansbacher, B., Royer, H.D. (2003) 'Efficiency of cytokine gene transfer in corneal endothelial cells and organ cultured corneas mediated by liposomal vehicles and recombinant adenovirus'. Ophthalmic Research, 35 :117-124 [Details]
(2003) 'Invited Review: Gene therapy in immune mediated diseases of the eye'
Pleyer, U., Ritter, T. (2003) 'Invited Review: Gene therapy in immune mediated diseases of the eye'. Progress in Retinal and Eye Research (PRER), 22 (3):277-293 [Details]
(2003) 'TNF-inhibitor gene expression suppresses lacrimal gland immunopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis'
Kawakami, N., Lassmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W.E.F., Ellwart, J.W., Bradl, M., Lassmann, H., Ransohoff, R.M., Volk, H.-D., Wekerle, H., Linington, C., Flügel, A. (2003) 'TNF-inhibitor gene expression suppresses lacrimal gland immunopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis'. Cornea, 22 :343-351 [Details]
(2003) 'Targeting of macrophage activity by adenovirus -mediated intragraft over-expression of TNFRp55-Ig, IL-12p40, and vIL-10 ameliorates whereas stimulation of macrophages by over-expression of IFN-? accelerates chronic graft injury in a rat renal allograft model'
Yang, J., Reutzel-Selke, A., Steier, C., Jurisch, A., Tullius, S.G., Sawitzki, B., Kolls, J., Volk, H.-D., Ritter, T (2003) 'Targeting of macrophage activity by adenovirus -mediated intragraft over-expression of TNFRp55-Ig, IL-12p40, and vIL-10 ameliorates whereas stimulation of macrophages by over-expression of IFN-? accelerates chronic graft injury in a rat renal allograft model'. J. Am. Soc. Nephrol, 14 :214-225 [Details]
(2003) 'Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice'
Sass, G., Soares, M.C., Yamashita, K., Seyfried, S., Zimmermann, W.H., Eschenhagen, T., Kaczmarek, E., Ritter, T., Volk, H.D., Tiegs, G. (2003) 'Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice'. Hepatology, 38 :909-918 [Details]
(2002) 'Invited review: Improvements in gene therapy: Averting the immune response to adenoviral vectors'
Ritter, T., Lehmann, M., Volk, H.-D. (2002) 'Invited review: Improvements in gene therapy: Averting the immune response to adenoviral vectors'. BioDrugs, 16 :3-10 [Details]
(2002) 'Intrabody-mediated phenotypic knock-out of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes'
Mhashilkar, A.M., Doebis, C., Seifert, C., Busch, A., Zani, C., Soo Hoo, J., Nagy, M., Ritter, T., Volk, H.-D., Marasco, W.A. (2002) 'Intrabody-mediated phenotypic knock-out of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes'. Gene Therapy, 9 :307-319 [Details]
(2002) 'Local delivery of the viral IL-10 gene suppresses tissue inflammation in murine P. carinii infection'
Ruan, S., Tate, C., Lee, J.J., Ritter, T., Kolls, J.K., Shellito, J.E. (2002) 'Local delivery of the viral IL-10 gene suppresses tissue inflammation in murine P. carinii infection'. Infect Immun, 70 :6107-6113 [Details]
(2002) 'Heme oxygenase 1 gene transfer prevents CD95/Fas Ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway'
Ke, B., Buelow, R., Shen, X.D., Melinek, J., Amersi, F., Gao, F., Ritter, T., Volk, H.-D-, Busuttil, R.W., Kupiec-Weglinski, J.W. (2002) 'Heme oxygenase 1 gene transfer prevents CD95/Fas Ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway'. Hum Gene Ther, 13 :1189-1199 [Details]
(2002) 'Antigen-dependent transgene expression in transplantation: a novel approach using gene-modified T lymphocytes'
Ke, B., Buelow, R., Shen, X.D., Melinek, J., Amersi, F., Gao, F., Ritter, T., Volk, H.-D-, Busuttil, R.W., Kupiec-Weglinski, J.W. (2002) 'Antigen-dependent transgene expression in transplantation: a novel approach using gene-modified T lymphocytes'. J. Am. Soc. Nephrol, 13 :511-518 [Details]
(2002) 'Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction'
Trousdale, M.D., Stevenson, D., Zhu, Z., Kaslow, H.R., Schechter, J.E., Warren, D.W., Azzarolo, A.M., Ritter, T., Mircheff, A.K. (2002) 'Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction'. Adv Exp Med Biol, 506 :789-794 [Details]
(2002) 'Expression of IL-10 and TNF-Inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes'
Zhu, Z., Stevenson, D., Ritter, T., Schechter, J.E., Mircheff, A.K., Kaslow, H.R., Trousdale, M.D. (2002) 'Expression of IL-10 and TNF-Inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes'. Cornea, 21 :210-214 [Details]
(2002) 'Efficient in vitro transduction of epithelial cells and keratinocytes with improved adenoviral gene transfer for the application in skin tissue engineering'
Doebis,C., Ritter, T., Brandt, C., Schonberger, B., Volk, H.-D., Seifert, M. (2002) 'Efficient in vitro transduction of epithelial cells and keratinocytes with improved adenoviral gene transfer for the application in skin tissue engineering'. Transplant Immunology, 9 :323-329 [Details]
(2002) 'Upregulation of Bag-1 by ex-vivo gene transfer protects rat livers from ischemia/reperfusion injury'
Sawitzki, B., Amersi, F., Ritter, T., Fisser, M., Shen, X-D., Busuttil, R., Volk, H.-D., Kupiec-Weglinski, J.W. (2002) 'Upregulation of Bag-1 by ex-vivo gene transfer protects rat livers from ischemia/reperfusion injury'. Human Gene Therapy, 13 :1495-1504 [Details]
(2001) 'Invited review: Corneal allograft rejection: Current understanding'
Pleyer, U., Dannowski, H., Volk, H.-D., Ritter, T. (2001) 'Invited review: Corneal allograft rejection: Current understanding'. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 215 :254-262 [Details]
(2001) 'Fibroblast-mediated delivery of growth factor genes into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer'
Gelse, K., Q.-J. Yang, Aigner, T., Ritter, T., Wagner, K., Pöschl, E., von der Mark, K., Schneider, H. (2001) 'Fibroblast-mediated delivery of growth factor genes into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer'. Arthritis & Rheum, 44 :1943-1953 [Details]
(2001) 'Homing of in vitro generated antigen-reactive CD4+ T lymphocytes to renal allografts is ?4?1- but not ?L?2-integrin dependent'
Hammer, M.H., Zhai, Y., Katori, M., Ritter, T., Volk, H.-D., Coito, A.J., Kupiec-Weglinski, J.W. (2001) 'Homing of in vitro generated antigen-reactive CD4+ T lymphocytes to renal allografts is ?4?1- but not ?L?2-integrin dependent'. J. Immunology, 166 :596-601 [Details]
(2001) 'Heme oxygenase-1 gene therapy: a novel immunomodulatory approach in liver allograft recipients?'
Ke, B., Shen, X.D., Melinek, J., Gao, F., Ritter, T., Volk, H.D., Busuttil, R.W., Kupiec-Weglinski, J.W. (2001) 'Heme oxygenase-1 gene therapy: a novel immunomodulatory approach in liver allograft recipients?'. Transplant Proc, 33 :581-582 [Details]
(2001) 'Visualization of alloantigen-specific, EGFP-engineered T lymphocytes in a rat kidney transplantation model'
Schröder, G., Hammer M.H., Risch, K., Flügel, A., Brock, J., Lehmann, M., Ritter, T., Volk, H.-D. (2001) 'Visualization of alloantigen-specific, EGFP-engineered T lymphocytes in a rat kidney transplantation model'. Transplant Proc, 33 :607-608 [Details]
(2001) 'Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis'
Flügel, A., Berkowicz T., Ritter, T., Labeur M., Jenne D.E., Li, Z., Ellwart J.W., Willem, M., Lassmann, H., Wekerle, H. (2001) 'Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis'. Immunity, 14 :547-560 [Details]
(2001) 'Gentherapie in der Ophthalmologie. Übersicht über Perspektiven und Möglichkeiten für Erkrankungen der Kornea'
Pleyer, U., Dannowski, H., Reszka, R., Volk, H.-D., Hartmann, C., Ritter, T. (2001) 'Gentherapie in der Ophthalmologie. Übersicht über Perspektiven und Möglichkeiten für Erkrankungen der Kornea'. Klin. Monatsblätter für Augenheilkunde, 218 :140-147 [Details]
(2001) 'Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride'
Sparmann, G., Behrend, S., Merkord, J., Kleine, H.-D., Graser, E., Ritter, T., Liebe, S., Emmrich, J. (2001) 'Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride'. Digestive Diseases and Sciences, 46 :1647-1656 [Details]
(2000) 'Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4'
Ritter, T., Schröder, G., Risch, K., Vergopoulos, A., Shean, M.K., Kolls, J., Brock, J., Lehmann, M., Volk, H.-D. (2000) 'Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4'. Graefes Arch Clin Exp Ophthalmol, 238 :531-536 [Details]
(2000) 'Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway'
Kato, H., Ritter, T., Ke, B., Murakami, M., Kusano, M., Busuttil, R.W., Kupiec-Weglinski J.W. (2000) 'Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway'. Transplant Proc, 32 :245-246 [Details]
(2000) 'Immune tolerance and gene therapy in transplantation'
Pleyer, U., Ritter, T., Volk, H.-D. (2000) 'Immune tolerance and gene therapy in transplantation'. Immunology today, 21 :12-14 [Details]
(2000) 'Stimulatory and inhibitory action of cytokines on the regulation of hCMV-promoter activity in human cell lines'
Flügel, A., Berkowicz T., Ritter, T., Labeur M., Jenne D.E., Li, Z., Ellwart J.W., Willem, M., Lassmann, H., Wekerle, H. (2000) 'Stimulatory and inhibitory action of cytokines on the regulation of hCMV-promoter activity in human cell lines'. Cytokine, 12 :1163-1170 [Details]
(2000) 'Regulatory cells potentiate the efficacy of IL 4 gene transfer in transplant recipients by upregulating Th2-dependent expression of protective molecules in the infectious tolerance pathway'
Ke, B., Ritter, T., Kato, H., Zhai, Y., Li, J., Busuttil, R.W., Lehmann M., Volk, H.-D., Kupiec-Weglinski, J.W. (2000) 'Regulatory cells potentiate the efficacy of IL 4 gene transfer in transplant recipients by upregulating Th2-dependent expression of protective molecules in the infectious tolerance pathway'. J. Immunol, 164 :5739-5745 [Details]
(2000) 'Immune response after adenoviral gene transfer in syngeneic heart transplants: effects of anti-CD4 mab therapy'
Ke, B., Ritter, T., Kato, H., Zhai, Y., Li, J., Busuttil, R.W., Lehmann M., Volk, H.-D., Kupiec-Weglinski, J.W. (2000) 'Immune response after adenoviral gene transfer in syngeneic heart transplants: effects of anti-CD4 mab therapy'. Transplantation, 70 :191-198 [Details]
(2000) 'Ischemia/Reperfusion injury mediated downregulation of adenovirus-mediated gene expression in a rat heart transplantation is inhibited by co-application of a TNFRp55-Ig chimeric construct'
Ritter, T., Schröder, G., Risch, K., Vergopoulos, A., Shean, M.K., Kolls, J., Brock, J., Lehmann, M., Volk, H.-D. (2000) 'Ischemia/Reperfusion injury mediated downregulation of adenovirus-mediated gene expression in a rat heart transplantation is inhibited by co-application of a TNFRp55-Ig chimeric construct'. Gene Therapy, 7 :1238-1243 [Details]
(1999) 'Upregulation of heme oxygenase-1 protects genetically fat zucker rats from ischemia/reperfusion injury'
Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.-D., Zhao, D., Zaky J., Melenik, J., Lassman, C.R., Kolls. J.K., Alam, J., Ritter, T., Volk, H.-D., Busuttil, R.W., Kupiec-Weglinski, J.W. (1999) 'Upregulation of heme oxygenase-1 protects genetically fat zucker rats from ischemia/reperfusion injury'. J. Clin. Invest, 104 :1631-1639 [Details]
(1999) 'Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2'
Onodera, K., Chandraker A., Volk, H.-D., Ritter, T., Lehmann, M., Sayegh, MH., Kupiec-Weglinski, .W. (1999) 'Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2'. Transplantation, 68 :288-293 [Details]
(1999) 'Intragraft overexpression of IL-4 is neither sufficient nor essential for tolerance induction in high-responder strain combination'
Ritter, T., Risch, K., Schröder, G., Kolls, J., Siegling, A., Graser, E., Reinke, P., Brock, J., Lehmann, M., Volk, H.-D (1999) 'Intragraft overexpression of IL-4 is neither sufficient nor essential for tolerance induction in high-responder strain combination'. Transplantation, 68 :1427-1431 [Details]
(1999) 'Depletion of IL-4 does not prevent tolerance induction in an allogeneic rat kidney transplantation model'
Ritter, T., Seifert, M., Risch, K., Fretz, A., Tanzmann, H., Brock, J., Volk, H.-D., Lehmann, M. (1999) 'Depletion of IL-4 does not prevent tolerance induction in an allogeneic rat kidney transplantation model'. Transplantation Proceedings, 31 :887-888 [Details]
(1999) 'Abolition of anti-CD4-induced allotransplantation tolerance by exogenous IL-2'
Ritter, T., Risch, K., Schröder, G., Kolls, J., Siegling, A., Graser, E., Reinke, P., Brock, J., Lehmann, M., Volk, H.-D. (1999) 'Abolition of anti-CD4-induced allotransplantation tolerance by exogenous IL-2'. Transplantation Proceedings, 31 :1220-1221 [Details]
(1999) 'Adenovirus-mediated gene transfer of IL-4 to corneal endothelial cells and rat corneas leads to high IL-4 expression'
Ritter, T, Vogt, K., Rieck, P., Schilling-Schön, A., Kolls, J., Hartmann, C., Volk, H.-D., Pleyer, U. (1999) 'Adenovirus-mediated gene transfer of IL-4 to corneal endothelial cells and rat corneas leads to high IL-4 expression'. Exp Eye Res, 69 :563-568 [Details]
(1999) 'Gene transfer of IL-4 prolongs rat renal allograft survival and inhibits p21ras dependent activation pathway'
Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.-D., Zhao, D., Zaky J., Melenik, J., Lassman, C.R., Kolls. J.K., Alam, J., Ritter, T., Volk, H.-D., Busuttil, R.W., Kupiec-Weglinski, J.W. (1999) 'Gene transfer of IL-4 prolongs rat renal allograft survival and inhibits p21ras dependent activation pathway'. Surg. Forum, 50 :381-383 [Details]
(1998) 'Immunreaktion nach perforierender Keratoplastik. II. Prävention und Therapie'
Pleyer, U., Rieck, P., Ritter, T., Hartmann C. (1998) 'Immunreaktion nach perforierender Keratoplastik. II. Prävention und Therapie'. Ophthalmologe, 95 :444-459 [Details]
(1998) 'Thymus requirement and antigen dependency in the „infectious“ tolerance pathway in transplant recipients'
Onodera, K., Volk, H.-D., Ritter, T., and Kupiec-Weglinski,, J.W. (1998) 'Thymus requirement and antigen dependency in the „infectious“ tolerance pathway in transplant recipients'. J. Immunology, 160 :5765-5772 [Details]
(1992) 'Specificity and T-cell -chain receptor usage of a human collagen type II-reactive T-cell clone derived from a healthy patient'
Lehmann, M., Risch, K., Nizze, H., Brandenburg, G., Ritter T., Brock, J., Volk, H.-D. (1992) 'Specificity and T-cell -chain receptor usage of a human collagen type II-reactive T-cell clone derived from a healthy patient'. Eur. J. Immunol, 22 :51-56 [Details]

Book Chapters

  Year Publication
(2016) 'Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection'
Treacy, O; Fahy, G; Ritter, T; O'Flynn, L. (2016) 'Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection' In: Suppression and Regulation of Immune Responses. New York: Springer New York. [Details]
(2012) 'Gene Therapy in Organ Transplantation'
Ritter T and Griffin MD (2012) 'Gene Therapy in Organ Transplantation' In: Molecular and Cellular Therapeutics. Hoboken, NJ, USA: Wiley. [Details]
(2004) 'Role of IL-10 in transplantation. Invited Review. Landes Bioscience, Ed. FM Marincola, 2004'
Ritter T., Volk, H.-D. (2004) 'Role of IL-10 in transplantation. Invited Review. Landes Bioscience, Ed. FM Marincola, 2004' In: [Details]

Conference Publications

  Year Publication
(2016) Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography
La, C,McGrath, J,Subhash, H,Rani, S,Ritter, T,Leahy, M,Manns, F,Soderberg, PG,Ho, A (2016) OPHTHALMIC TECHNOLOGIES XXVI Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography [DOI] [Details]
(2016) Licensing of recipient-derived mesenchymal stem cells enhances their immunosuppressive properties and prolongs corneal allograft survival in rats
Treacy, O,Murphy, N,Ryan, AE,Lohan, P,Lynch, K,Morcos, M,Fahy, G,Griffin, M,Ritter, T (2016) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Licensing of recipient-derived mesenchymal stem cells enhances their immunosuppressive properties and prolongs corneal allograft survival in rats [Details]
(2015) ALLOGENEIC CHONDROPROGENITORS DISPLAY IMMUNOSUPPRESSIVE PROPERTIES AND ARE NON-IMMUNOGENIC IN VITRO
Lohan, P,Treacy, O,Lynch, K,Griffin, M,Ritter, T,Ryan, AE (2015) OSTEOARTHRITIS AND CARTILAGE ALLOGENEIC CHONDROPROGENITORS DISPLAY IMMUNOSUPPRESSIVE PROPERTIES AND ARE NON-IMMUNOGENIC IN VITRO , pp.267-267 [Details]
(2015) Mesenchymal stem cell-derived extracellular vesicles promote corneal wound repair
Ritter, T,O'Malley, GA,Lohan, P,Ryan, A,Griffin, M,Rani, S (2015) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Mesenchymal stem cell-derived extracellular vesicles promote corneal wound repair [Details]
(2012) RAMI Biomedical Sciences Conference Galway
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) MECHANISM OF ACTION OF ANTI-INFLAMMATORY EFFECTS OF INTERLEUKIN-10 OVEREXPRESSING MESENCHYMAL STEM CELLS RAMI Biomedical Sciences Conference Galway [Details]
(2012) Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis , pp.63-63 [Details]
(2012) Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE , pp.63-63 [Details]
(2011) Role of lentivirus-mediated overexpression of Programmed Death Ligand 1 on corneal allograft survival
Ritter, T,Wilk, M,Morcos, M,Cregg, M,O'Flynn, L,Treacy, O,Nosov, M (2011) HUMAN GENE THERAPY Role of lentivirus-mediated overexpression of Programmed Death Ligand 1 on corneal allograft survival , pp.78-78 [Details]
(2011) Modulation of the In Vitro Microenvironment of Corneal Keratocytes Using Macromolecular Crowding. 24th European Society for Biomaterials, 4th-8th of September, Dublin, Ireland, 2011
Kumar, P., Satyam, A., Ritter, T., Raghunath, M., Pandit, A. and Zeugolis, D.I. (2011) Modulation of the In Vitro Microenvironment of Corneal Keratocytes Using Macromolecular Crowding. 24th European Society for Biomaterials, 4th-8th of September, Dublin, Ireland, 2011 [Details]
(2011) Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation
Treacy, O,Heinzl, T,Cregg, M,Wilk, M,Odoardi, F,O'Brien, T,Ryan, A,Nosov, M,Ritter, T (2011) Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation , pp.72-72 [Details]
(2010) Mesenchymal stem cell function in Inflammatory Arthritis. IRISH JOURNAL OF MEDICAL SCIENCE
Malone-Sullivan, C,Murphy, M,Ritter, T,Barry, F (2010) Mesenchymal stem cell function in Inflammatory Arthritis. IRISH JOURNAL OF MEDICAL SCIENCE [Details]

Abstract

  Year Publication
(2014) Development of a flow cytometry-based potency assay for the immunomodulatory properties of mesenchymal stromal cells.
Ribeiro, A,Ritter, T,Griffin, M,Ceredig, R (2014) Development of a flow cytometry-based potency assay for the immunomodulatory properties of mesenchymal stromal cells. Abstract [Details]
(2014) Allogeneic rat articular chondrocytes are weakly immunogenic and display potent immunosuppressive ability in vitro.
Lohan, P,Treacy, O,Lynch, K,Coleman, C,Ryan, AE,Ritter, T (2014) Allogeneic rat articular chondrocytes are weakly immunogenic and display potent immunosuppressive ability in vitro. Abstract [Details]
(2010) Mesenchymal stem cell function in Inflammatory Arthritis.
Malone-Sullivan, C,Murphy, M,Ritter, T,Barry, F (2010) Mesenchymal stem cell function in Inflammatory Arthritis. Abstract [Details]
(2009) Tolerance Associated Gene 1 Inhibits TLR4 Mediated p38 MAP Kinase Activation, Dendritic Cell Maturation and Subsequent T Cell Priming.
Vogel, S,Schlickeiser, S,Appelt, C,Schliesser, U,Keeren, K,Vogt, K,Guerreiro, M,Ritter, T,Volk, D,Sawitzki, B (2009) Tolerance Associated Gene 1 Inhibits TLR4 Mediated p38 MAP Kinase Activation, Dendritic Cell Maturation and Subsequent T Cell Priming. Abstract [Details]

Editorial

  Year Publication
(2005) Is ex vivo adenovirus mediated gene transfer a therapeutic option for the treatment of corneal diseases?.
Ritter, T,Gong, N,Pleyer, U (2005) Is ex vivo adenovirus mediated gene transfer a therapeutic option for the treatment of corneal diseases?. Editorial [DOI] [Details]

Reviews

  Year Publication
(2001) Regulatory tolerance-mediating T cells in transplantation tolerance. Transplant Proc.
Sawitzki, B., Lehmann, M., Ritter, T., Graser, E., Kupiec-Weglinski, J.W., Volk, H.D. (2001) Regulatory tolerance-mediating T cells in transplantation tolerance. Transplant Proc. Reviews [Details]

Employment

  Employer Position From / To
National University of Ireland Galway Personal Professor of Medicine 01-JAN-15 /
National University of Ireland Galway Senior Lecturer of Medicine 01-JUN-09 / 31-DEC-14
National University of Ireland, Galway Lecturer in Medicine (Gene Therapy) 01-MAR-05 / 31-MAY-09
Centre of Immunology, Marseille (France) Post-Doc 01-MAR-94 / 31-MAR-95
Charité - University Medicine Berlin Group leader (C1) 01-APR-95 / 31-MAR-05

Honours and Awards

  Year Title Awarding Body
2002 Privatdozent Humboldt-University Berlin, Germany

Professional Associations

  Association Function From / To
Association for Vision and Reasearch in Ophthalmology Member /
German Society for Gene and Cell Therapy Member /
German Society of Immunology Member /
American Society for Gene and Cell Therapy Member /

Education

  Year Institution Qualification Subject
1994 Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany PhD Immunology
1989 Friedrich-Alexander Universitaet Erlangen Nuernberg, Germany Diploma Biology

Languages

  Language
German
French