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Medicine

Dr Cynthia Coleman

PhD

Contact Details

Research Fellow
First Floor South
Biosciences Research Building
National University of Ireland
Galway

T: Ext. 5852
E: cynthia.coleman@nuigalway.ie
 
researcher

Biography

Cynthia's current research investigations focus on identifying and validating cellular therapies to treat orthopaedic disorders ranging from osteoporosis and cartilage regeneration to long bone fracture healing.  She leads a research program 1) investigating the aetiology of diabetes-induced osteopathy and 2) applying adult human marrow-derived mesenchymal stem cells to repair diabetic long bone fractures.  These studies investigate the molecular basis for diabetes-induced progenitor cell dysfunction resulting in deficient bone homeostasis.  As she has demonstrated that supplementing diabetic fracture repair with non-diabetic progenitor cells enhances the mechanical integrity of the repairing bone, her current investigations will elucidate the molecular basis underpinning this cellular dysfunction.  This program has resulted in establishing a new in vivo model of fracture repair at NUIG and the creation of a highly sensitive high-throughput, regulatory body approved methodology to detect the biodistribution of therapeutic progenitor cells.  These investigations are in collaboration with 10 international academic and industrial partners, a clinical team at Galway University Hospital and the patient advocacy group Diabetes Ireland.

Research Interests

Diabetes Induced Osteopathy
Bone Fracture Repair
Cartilage Repair
Skeletal Development
Joint Development
Patient Perceptions of Diabetes-Induced Osteopathy
Impact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish Patients
Coral as a Bone Substitute

Research Projects

  Project Start Date End Date
Identifying the Aetiology of Diabetic Progenitor Cell Dysfunction in Osteoporosis 01-NOV-16 31-OCT-18
Investigating Cell Ingrowth into a Natural Bone Replacement Scaffold 01-NOV-16 31-OCT-17
PURESTEM: Utilization of the Mesenchymal Stem Cell Receptome for Rational Development of Uniform, Serum-free Conditions and Tools for Cell Characterization 01-NOV-08 01-NOV-10
REDDSTAR: Repair of Diabetic Damage by Stromal Cell Administration 01-NOV-12 01-NOV-15

Peer Reviewed Journals

  Year Publication
(2017) 'Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction based detection of human DNA in murine organs'
Creane, M,Howard, L,O'Brien, T,Coleman, CM (2017) 'Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction based detection of human DNA in murine organs'. Cytotherapy, 19 :384-394 [DOI] [Details]
(2015) 'Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect'
Barron, V,Merghani, K,Shaw, G,Coleman, CM,Hayes, JS,Ansboro, S,Manian, A,O'Malley, G,Connolly, E,Nandakumar, A,van Blitterswijk, CA,Habibovic, P,Moroni, L,Shannon, F,Murphy, JM,Barry, F (2015) 'Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect'. Annals Of Biomedical Engineering, 43 :2069-2082 [DOI] [ARAN Link] [Details]
(2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'
Bulman, SE,Coleman, CM,Murphy, JM,Medcalf, N,Ryan, AE,Barry, F (2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'. Stem Cell Research & Therapy, 6 [DOI] [Details]
(2014) 'Chondrogenic Differentiation Increases Host Immune Response to Allogeneic Mesenchymal Stem Cell (MSC) Transplantation'
Ryan, A; Lohan, P; O'Flynn, L; Treacy, O; Chen, X; Coleman, CM; Shaw, G; Murphy, M; Barry, F; Griffin, M; Ritter, T (2014) 'Chondrogenic Differentiation Increases Host Immune Response to Allogeneic Mesenchymal Stem Cell (MSC) Transplantation'. Molecular Therapy, 22 (3):655-667 [Details]
(2013) 'Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy'
Coleman, CM,Vaughan, EE,Browe, DC,Mooney, E,Howard, L,Barry, F (2013) 'Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy'. Stem Cells And Development, 22 :1968-1976 [DOI] [Details]
(2012) 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'
Vaughan, E; Liew, A; Mashayekhi, K; Dockery, P; McDermott, J; Kealy, B; Flynn, A; Duffy, A; Coleman, C.M.; O'Regan A; Barry, F; O'Brien, T. (2012) 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'. Cell Transplantation, 21 (6):1095-1107 [Details]
(2012) 'A role for MRP8 in in stent restenosis in diabetes'
Stocca, A; O'Toole, D; Hynes, N; Hynes, S; Mashayekhi, K; McGinley, L; Coleman, C.M; Sultan, S; Duffy, A; Tuney, T; O'Brien, T (2012) 'A role for MRP8 in in stent restenosis in diabetes'. Atherosclerosis, 221 (2):325-332 [Details]
(2011) 'Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study'
Coleman, CM,Scheremeta, BH,Boyce, AT,Mauck, RL,Tuan, RS (2011) 'Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study'. Clinical Orthopaedics And Related Research, 469 :2915-2924 [DOI] [Details]
(2003) 'Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos'
Chatterjee, B; Meyer, R; Loredo, G; Coleman, C.M; Tuan, R; Lo, C (2003) 'Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos'. Cell Adhesion and Communication, 10 (1):37-50 [Details]
(2003) 'Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells'
Coleman, C.M.; Tuan, R (2003) 'Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells'. Mechanisms Of Development, 120 (7):823-836 [Details]
(2003) 'Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation'
Coleman, C.M; Tuan, R.S. (2003) 'Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation'. Developmental Dynamics, 228 (2):208-216 [Details]
(2003) 'Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development'
Coleman, C.M.; Loredo, G.A.; Lo, C.W.; Tuan, R (2003) 'Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development'. Anatomical Record, 275 (A):1117-1121 [Details]

Conference Publications

  Year Publication
(2010) European Cells and Materials
Bulman, S; Coleman, C.M; Murphy, M; Barry, F; (2010) Pullulan enhances progenitor cell attachment on OA cartilage European Cells and Materials [Details]
(2010) Fracture healing in GDF-5 deficient mice
Coleman, CM,Scheremeta, BH,Boyce, A,Mauck, RL,Tuan, RS (2010) INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Fracture healing in GDF-5 deficient mice , pp.18-18 [Details]
(2010) hMSC TNAP expression is a marker of differentiation potential
D'Arcy, S,Coleman, CM,Murphy, JM,Barry, F (2010) INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY hMSC TNAP expression is a marker of differentiation potential , pp.11-11 [Details]
(2010) European Cells and Materials
O'Sullvian, J; Coleman, C.M.; Murphy, M; Barry F (2010) Selection of chondroprogenitors from bone marrow by adhesion to chondroitin sulfate European Cells and Materials [Details]

Conference Contributions

  Year Publication
(2013) GDF-5: From the Embryo to the Clinic,
CM Coleman (2013) Overview of the scientific advancements in GDF-5 research to the clinic. [Invited Lecture], GDF-5: From the Embryo to the Clinic, Trinity College Dublin , 01-FEB-13 - 01-FEB-13. [Details]
(2012) Histology of Cartilage and Bone,
Coleman, Hayes, Murphy, Barry (2012) Insight into modern techniques of preserving, staining and imaging orthopaedic tissue. [Conference Organising Committee Chairperson], Histology of Cartilage and Bone, Galway , 01-JUN-12 - 01-JUN-12. [Details]
(2012) Royal Academy of Medicine in Ireland,
Loftus, Coleman, Barry (2012) Mesenchymal stem Cell Chondrogenesis is Enhanced with Lentiviral Overexpression of Growth Differentiation Factor 5. [Poster Presentation (Refereed)], Royal Academy of Medicine in Ireland, Galway , 01-JUN-12 - 01-JUN-12. [Details]
(2012) MSC Galway 2012: International Mesenchymal Stem Cell Conference,
Coleman, Shaw, Burke, Joyce, Barron, Murphy, Barry (2012) High Throughput Characterization of the Mesenchymal Stem Cell Surface Phenotype. [Poster Presentation (Refereed)], MSC Galway 2012: International Mesenchymal Stem Cell Conference, Galway , 01-JUN-12 - 01-JUN-12. [Details]
(2012) MSC Galway 2012: International Mesenchymal Stem Cell Conference,
Burke, Shaw, Murphy, Coleman, Barron, McGonagle, Jones, Soukup, Cancedda, Gentili, Barry (2012) Intra-Laboratory Validation of Optimized MSC Culture and Standard Operating Procedures for Current Best Practice MSC Methods. [Poster Presentation (Refereed)], MSC Galway 2012: International Mesenchymal Stem Cell Conference, Galway , 01-JUN-12 - 01-JUN-12. [Details]
(2012) MSC Galway 2012: International Mesenchymal Stem Cell Conference,
Browe, Elliman, Coleman, Barry (2012) Hypoxia Attenuates Hypertrophy of MSC-Derived Cartilage. [Poster Presentation], MSC Galway 2012: International Mesenchymal Stem Cell Conference, Galway , 01-JUN-12 - 01-JUN-12. [Details]
(2012) MSC Galway 2012: International Mesenchymal Stem Cell Conference,
Coleman, Murphy, Barry (2012) Adipose Derived Stromal Cells for Osteoarthritis Treatment: An In Vivo Caprine Study. [Poster Presentation], MSC Galway 2012: International Mesenchymal Stem Cell Conference, Galway , 01-JUN-12 - 01-JUN-12. [Details]
(2011) Orthopaedic Research Society,
D'Arcy, Coleman, Murphy, Barry (2011) hMSC TNAP Expression is a Marker of Differentiation Potential. [Oral Presentation], Orthopaedic Research Society, Long Beach, USA , 01-JAN-11 - 01-JAN-11. [Details]
(2011) Orthopaedic Research Society,
Coleman, Curtin, Barry (2011) GDF-5 Supplementation Enhances hMSC Chondrogenesis. [Oral Presentation], Orthopaedic Research Society, Long Beach, USA , 01-JAN-11 - 01-JAN-11. [Details]
(2011) International Society for Cellular Therapy,
Burke, Shaw, Murphy, Coleman, Barron, McGonagle, Jones, Soukup, Cancedda, Gentili, Barry (2011) Intra-Laboratory Validation of Optimized MSC Culture and Standard Operating Procedures for Current Best Practice MSC Methods. [Poster Presentation (Refereed)], International Society for Cellular Therapy, Rotterdam , 01-MAY-11 - 01-MAY-11. [Details]
(2011) Orthopaedic Research Society,
Bulman, Coleman, Murphy, Barry (2011) Pullulan Enhances Progenitor Cell Attachment on Osteoarthritic Cartilage. [Poster Presentation (Refereed)], Orthopaedic Research Society, Long Beach , 01-JAN-11 - 01-JAN-11. [Details]
(2011) International Society for Cellular Therapy,
Coleman, Shaw, Burke, Joyce, Barron, Murphy, Barry (2011) High Throughput Characterization of the Mesenchymal Stem Cell Surface Phenotype. [Poster Presentation (Refereed)], International Society for Cellular Therapy, Rotterdam , 01-MAY-11 - 01-MAY-11. [Details]
(2011) TERMIS,
Burke, Shaw, Murphy, Coleman, Barron, McGonagle, Jones, Soukup, Cancedda, Gentili, Barry (2011) Intra-Laboratory Validation of Optimized MSC Culture and Standard Operating Procedures for Current Best Practice MSC Methods. [Poster Presentation (Refereed)], TERMIS, Granada , 01-JUN-11 - 01-JUN-11. [Details]
(2011) TERMIS,
Mooney, Ansboro, Shaw, Coleman, Barron, Barry, Murphy (2011) Optimising Extracellular Matrix Coatings for MSC Attachment and Proliferation in Serum-Free Culture Conditions. [Poster Presentation (Refereed)], TERMIS, Granada , 01-JUN-11 - 01-JUN-11. [Details]
(2011) International Society for Cellular Therapy,
Mooney, Ansboro, Shaw, Coleman, Barron, Barry, Murphy (2011) Optimising Extracellular Matrix Coatings for MSC Attachment and Proliferation in Serum-Free Culture Conditions. [Poster Presentation (Refereed)], International Society for Cellular Therapy, Rotterdam , 01-MAY-11 - 01-MAY-11. [Details]
(2010) eCells & Materials Meeting,
O'Sullivan, Coleman, Murphy, Barry (2010) Selective Adhesion of MSCs to Extracellular Matrix Molecules Enhances Progenitor Isolation from Bone Marrow. [Poster Presentation (Refereed)], eCells & Materials Meeting, Davos , 01-JUN-10 - 01-JUN-10. [Details]
(2010) 4th UK Mesenchymal Stem Cell Meeting,
O'Sullivan, Coleman, Murphy, Barry (2010) Selective Adhesion of MSCs to Extracellular Matrix Molecules Enhances Progenitor Isolation from Bone Marrow. [Poster Presentation (Refereed)], 4th UK Mesenchymal Stem Cell Meeting, Leeds , 01-APR-10 - 01-APR-10. [Details]
(2010) British Society for Matrix Biology,
O'Sullivan, Coleman, Murphy, Barry (2010) Selective Adhesion of MSCs to Extracellular Matrix Molecules Enhances Progenitor Isolation from Bone Marrow. [Poster Presentation (Refereed)], British Society for Matrix Biology, Manchester , 01-MAR-10 - 01-MAR-10. [Details]
(2010) TERMIS EU 2010,
Coleman (2010) Co-organizer of TERMIS EU 2010 sessions. [Conference Organising Committee Member], TERMIS EU 2010, Galway , 01-JUN-10 - 01-JUN-10. [Details]
(2010) Orthopaedic Research Society,
O'Sullivan, Coleman, Murphy, Barry (2010) Selective Adhesion of MSCs to Extracellular Matrix Molecules Enhances Progenitor Isolation from Bone Marrow. [Poster Presentation (Refereed)], Orthopaedic Research Society, New Orleans , 01-MAR-10 - 01-MAR-10. [Details]
(2010) International Cartilage Repair Society, Barcelona,
Coleman, Curtin, Barry (2010) GDF-5 Supplementation Enhances hMSC Chondrogenesis. [Poster Presentation (Refereed)], International Cartilage Repair Society, Barcelona, Barcelona , 01-SEP-10 - 01-SEP-10. [Details]
(2010) International Cartilage Repair Society,
Coleman, Curtin, Barry (2010) GDF-5 Supplementation Enhances hMSC Chondrogenesis. [Poster Presentation (Refereed)], International Cartilage Repair Society, Barcelona , 01-SEP-10 - 01-SEP-10. [Details]
(2010) British Society for Matrix Biology,
Coleman, Curtin, Barry (2010) GDF-5 Supplementation Enhances hMSC Chondrogenesis. [Poster Presentation (Refereed)], British Society for Matrix Biology, Manchester , 01-MAR-10 - 01-MAR-10. [Details]
(2010) 4th UK Mesenchymal Stem Cell Meeting,
Coleman, Curtin, Barry (2010) GDF-5 Supplementation Enhances hMSC Chondrogenesis. [Poster Presentation (Refereed)], 4th UK Mesenchymal Stem Cell Meeting, Leeds , 01-APR-10 - 01-APR-10. [Details]
(2010) International Cartilage Repair Society,
D'Arcy, Coleman, Murphy, Barry (2010) hMSC TNAP Expression is a Marker of Differentiation Potential. [Poster Presentation (Refereed)], International Cartilage Repair Society, Barcelona , 01-SEP-10 - 01-SEP-10. [Details]
(2010) TERMIS EU 2010,
O'Sullivan, Coleman, Murphy, Barry (2010) Selective Adhesion of MSCs to Extracellular Matrix Molecules Enhances Progenitor Isolation from Bone Marrow. [Oral Presentation], TERMIS EU 2010, Galway , 01-JUN-10 - 01-JUN-10. [Details]
(2010) Orthopaedic Research Society,
Ryan, Coleman, Murphy, Barry (2010) hMSC Interaction with Environmental Hyaluronan influences Chondrogenic Differentiation. [Poster Presentation (Refereed)], Orthopaedic Research Society, New Orleans , 01-MAR-10 - 01-MAR-10. [Details]
(2010) TERMIS EU 2010,
Ryan, Coleman, Murphy, Barry (2010) hMSC Interaction with Environmental Hyaluronan influences Chondrogenic Differentiation. [Poster Presentation (Refereed)], TERMIS EU 2010, Galway , 01-JUN-10 - 01-JUN-10. [Details]
(2010) TERMIS EU 2010,
Coleman, Howard, Curtin, Barry (2010) GDF-5 Supplementation Enhances hMSC Chondrogenesis. [Oral Presentation], TERMIS EU 2010, Galway , 01-JUN-10 - 01-JUN-10. [Details]
(2010) International Cartilage Repair Society,
O'Sullivan, Coleman, Murphy, Barry (2010) Selective Adhesion of MSCs to Extracellular Matrix Molecules Enhances Progenitor Isolation from Bone Marrow. [Poster Presentation (Refereed)], International Cartilage Repair Society, Barcelona , 01-SEP-10 - 01-SEP-10. [Details]
(2010) eCells & Materials,
Bulman, Coleman, Murphy, Barry (2010) Pullulan Enhances Progenitor Cell Attachment on Osteoarthritic Cartilage. [Poster Presentation (Refereed)], eCells & Materials, Davos , 01-JUN-10 - 01-JUN-10. [Details]
(2010) British Society for Matrix Biology,
D'Arcy, Coleman, Murphy, Barry (2010) hMSC TNAP Expression is a Marker of Differentiation Potential. [Poster Presentation (Refereed)], British Society for Matrix Biology, Manchester , 01-MAR-10 - 01-MAR-10. [Details]
(2010) 4th UK Mesenchymal Stem Cell Meeting,
D'Arcy, Coleman, Murphy, Barry (2010) hMSC TNAP Expression is a Marker of Differentiation Potential. [Poster Presentation (Refereed)], 4th UK Mesenchymal Stem Cell Meeting, Leeds , 01-APR-10 - 01-APR-10. [Details]
(2010) eCells & Materials Meeting,
D'Arcy, Coleman, Murphy, Barry (2010) hMSC TNAP Expression is a Marker of Differentiation Potential. [Poster Presentation (Refereed)], eCells & Materials Meeting, Davos , 01-JUN-10 - 01-JUN-10. [Details]
(2009) Orthopaedic Research Society,
Hutson, Coleman, Freestone, Murphy, Barry (2009) Hyaluronic Acid as a Cryopreservant of Mesenchymal Stem Cells. [Poster Presentation (Refereed)], Orthopaedic Research Society, Las Vegas , 01-FEB-09 - 01-FEB-09. [Details]
(2009) British Society for Matrix Biology,
Ryan, Coleman, Murphy, Barry (2009) hMSC Interaction with Environmental Hyaluronan influences Chondrogenic Differentiation. [Poster Presentation (Refereed)], British Society for Matrix Biology, London , 01-JUN-09 - 01-JUN-09. [Details]
(2009) Orthopaedic Research Society,
Coleman (2009) Co-chair of the Bone Fracture session. [Co-chaired Session], Orthopaedic Research Society, Las Vegas , 01-FEB-09 - 01-FEB-09. [Details]
(2009) British Society for Matrix Biology,
Coleman, Scheremeta, Mauck, Boyce, Tuan (2009) Fracture Healing in GDF-5 Deficient Mice. [Poster Presentation (Refereed)], British Society for Matrix Biology, London , 01-JUN-09 - 01-JUN-09. [Details]
(2009) British Society for Matrix Biology,
Coleman, Scheremeta, Mauck, Boyce, Tuan (2009) Fracture Healing in GDF-5 Deficient Mice. [Oral Presentation], British Society for Matrix Biology, London , 01-JUN-09 - 01-JUN-09. [Details]
(2009) British Society for Matrix Biology,
Ryan, Coleman, Murphy, Barry (2009) hMSC Interaction with Environmental Hyaluronan influences Chondrogenic Differentiation. [Oral Presentation], British Society for Matrix Biology, London , 01-JUN-09 - 01-JUN-09. [Details]
(2008) Gordon Conference,
Mylotte, Szegezdi, O'Brien, Murphy, Coleman, Barry (2008) Investigation of Chondrogenic Differentiation of MSCs in a Hypoxic Environment. [Poster Presentation (Refereed)], Gordon Conference, Andover , 01-JUL-08 - 01-JUL-08. [Details]
(2008) Irish Society for Gene & Cell Therapy,
Kavanagh, Sloane, Dwyer, Coleman, O'Brien, Barry (2008) Mesenchymal Stem Cell Migration in Response to a Myocardial Infarct-Produced Chemokine Stimulus. [Poster Presentation (Refereed)], Irish Society for Gene & Cell Therapy, Cork , 01-MAY-08 - 01-MAY-08. [Details]
(2008) Tissue & Cell Engineering Society,
Barry, Murphy, Coleman, O'Brien, Rae, Duffy (2008) Mesenchymal Stem Cells: Characterization, Therapeutic Evaluation and Manufacturing. [Oral Presentation], Tissue & Cell Engineering Society, Nottingham , 01-JUL-08 - 01-JUL-08. [Details]
(2008) European Society of Sports Traumatology Knee Surgery and Arthroscopy,
Curtin, Coleman, Murphy, Barry (2008) Allogenic Mesenchymal Stem Cells for Regenerative Medicine. [Oral Presentation], European Society of Sports Traumatology Knee Surgery and Arthroscopy, Porto , 01-MAY-08 - 01-MAY-08. [Details]
(2008) Hilton Head Workshop,
Kavanagh, Sloane, Dwyer, Coleman, O'Brien, Barry (2008) Myocardial Infarct-Produced Chemokine Stimulus Promotes Stem Cell Migration. [Oral Presentation], Hilton Head Workshop, Hilton Head , 01-MAR-08 - 01-MAR-08. [Details]
(2008) Orthopaedic Research Society,
Mylotte, Coleman, Murphy, Samali, Szegezdi, Barry (2008) Metabolic Flexibility of Mesenchymal Stem Cells Supports Their Use In Cartilage Repair. [Oral Presentation], Orthopaedic Research Society, San Diego , 01-MAR-08 - 01-MAR-08. [Details]
(2008) Workshop for Small Animal SPECT Imaging,
Duffy, Kavanagh, Mooney, Coleman, Bowes, O'Brien, Barry (2008) Novel Techniques for the Retrieval of Engrafted Mesenchymal Stem Cells from the Injured Myocardium. [Oral Presentation], Workshop for Small Animal SPECT Imaging, Tuscon , 01-JAN-08 - 01-JAN-08. [Details]
(2008) Hilton Head Workshop,
Liew, Bowes, Coleman, Greiser, O'Brien (2008) Endothelial Progenitor Cell Dysfunction in Diabetes Mellitus: A Role for Osteopontin. [Oral Presentation], Hilton Head Workshop, Hilton Head , 01-MAR-08 - 01-MAR-08. [Details]
(2006) International Cartilage Repair Society,
Dhanaraj, Wang, Kong, Coleman, Binette, Geesin (2006) rhGDF-5 Enhances New Cartilage Formation In Cartilage Fragment-Loaded Scaffolds. [Oral Presentation], International Cartilage Repair Society, San Diego , 01-JAN-06 - 01-JAN-06. [Details]
(2005) Orthopaedic Research Society,
Scheremeta, Coleman, Mauck, Boyce, Bicksler, Tuan (2005) Impaired Endochondral Ossification in Tibial Fractures of Brachypod Mice Limits Mechanical Stability of Healed Bone. [Oral Presentation], Orthopaedic Research Society, Washington DC , 01-FEB-05 - 01-FEB-05. [Details]

Review Articles

  Year Publication
(2010) Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?.
C.M. Coleman, C. Curtin, F. Barry, J.M. Murphy. (2010) Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?. Review Articles [DOI] [Details]

Reviews

  Year Publication
(2016) Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm.
J. Hayes, C.M. Coleman. (2016) Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm. Reviews [Details]
(2014) From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair.
Watson, L,Elliman, SJ,Coleman, CM (2014) From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair. Reviews [DOI] [Details]
(2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?.
Lohan, P,Coleman, CM,Murphy, M,Griffin, MD,Ritter, T,Ryan, AE (2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?. Reviews [DOI] [Details]
(2013) Enhancing the Mesenchymal Stem Cell Therapeutic Response: Cell Localization and Support for Cartilage Repair.
Bulman, SE,Barron, V,Coleman, CM,Barry, F (2013) Enhancing the Mesenchymal Stem Cell Therapeutic Response: Cell Localization and Support for Cartilage Repair. Reviews [DOI] [Details]
(2011) Mesenchymal chondroprogenitor cell origin and therapeutic potential.
O'Sullivan, J,D'Arcy, S,Barry, FP,Murphy, JM,Coleman, CM (2011) Mesenchymal chondroprogenitor cell origin and therapeutic potential. Reviews [DOI] [Details]
(2008) Chicken Embryo as a Model for Regenerative Medicine.
Coleman, C.M; (2008) Chicken Embryo as a Model for Regenerative Medicine. Reviews [Details]
(2003) Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton.
Shum, L; Coleman, C.M; Hatakeyama, Y; Tuan, R (2003) Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton. Reviews [Details]

Honours and Awards

  Year Title Awarding Body
2017 Invited speaker at Diabetes Ireland Conference & Exhibition Diabetes Ireland
2016 Invited speaker at Molecular Medicine Ireland Molecular Medicine Ireland
2013 Invited speaker at Trinity College Dublin Trinity College Dublin
2011 NCBES Post-Doctoral Research Award NCBES Faculty
1997 Doctoral Foerderer Fellowship Thomas Jefferson University
1998 Doctoral Foerderer Fellowship Thomas Jefferson University
1999 Doctoral Foerderer Fellowship Thomas Jefferson University
2000 Grant in Aid Research Award Sigma Xi
2003 Post-doctoral intramural research training fellowship National Institutes of Health
2002 Post-doctoral intramural research training fellowship National Institutes of Health
2009 Annual Meeting Session Chair: Bone Fracture Repair Orthopaedic Research Society
2008 Annual Meeting Session Chair: Bone Fracture Repair Orthopaedic Research Society
2010 Cover Photograph Human Gene Therapy
2010 Best Abstract International Cartilage Repair Society (Barcelona)

Professional Associations

  Association Function From / To
Orthopaedic Research Society Member 01-JAN-05 / 27-JUN-17
Irish Endocrine Society member 01-JUN-17 / 27-JUN-17

Patents

  Patent Number Title Granted
EP1784142 A2 Musculo-skeletal implant having a bioactive gradient 29-JUL-05

Committees

  Committee Function From / To
Regenerative Medicine Institute Executive Management Committee member 01-JAN-17 / 27-JUN-17
NUI Galway Post-Graduate Strategy Committee member 01-NOV-16 / 27-JUN-17

Employment

  Employer Position From / To
National Institutes of Health Post Doctoral Fellow 01-NOV-02 / 01-JAN-04
National University of Ireland Galway Senior Scientist in Orthobiologics 10-JAN-07 /
Johnson & Johnson Regenerative Therapeutics Senior Scientist in Cell Biology and Preclinical Evaluation 01-JAN-04 / 01-DEC-06
National University of Ireland Galway Research Fellow in Orthobiologics 01-JAN-13 /
National University of Ireland Galway Honorary Research Lecturer in Orthobiologics 01-JAN-10 /

Education

  Year Institution Qualification Subject
2002 Thomas Jefferson University PhD Developmental Biology and Teratology
1997 Saint Michael's College BSc Biology, Minor in Chemistry

Languages

  Language
English

Consultancy

  Client Description
Zoan Biomed
Scientific Advisory Board

Community Engagement

  Title Type From / To
Outreach Invited speaker at “Diabetes Ireland Conference & Exhibition" /
Outreach Clinical Research Facility Galway open day guide and educator /
Outreach Reel Life Science adjudicator /
Teaching (e.g. Service learning / comunity based learning) Transition year student mentoring /
Outreach Local judge in Debating Science Issues /
Outreach National judge in Debating Science Issues /
Outreach Invited speaker at “Diabetes: It’s Complicated” /

Reviews

  Journal Role
Scientific Reports Reviewer
Tissue Engineering Reviewer
Cells Tissues Organs Reviewer
Scientific Reports Reviewer
Journal Of Tissue Engineering And Regenerative Medicine Reviewer
Experimental Biology And Medicine Reviewer
Journal Of Orthopaedic Research Reviewer
Life Sciences Reviewer
Cell Transplantation Reviewer
Connective Tissue Research Reviewer
Irish Journal Of Medical Science Reviewer
Biomed Research International Reviewer
Regenerative Medicine Reviewer
Arthritis Research & Therapy Reviewer
Pnas Reviewer
Acta biochimica et biophysica Sinica Reviewer
Stem Cell Research & Therapy Reviewer

Other Activities

  Description

Review of grant proposals for: • Biotechnology & Bioresearch Sciences Research Council • Medical Research Council UK • Netherlands Organisation for Health Research and Development

Teaching Interests

Anatomy of Cartilage
Anatomy of Bone
Applied Anatomy: The Repair of Cartilage and Bone
Regulatory Aspects of Product Development
Scientific Writing
Pre-clinical Development of Cellular Therapies

Current Postgraduate Students (Taught)

  Name Degree Primary Supervisor
Sophie Maybury Msc Y

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2013 Sarah Flood Msc Y
2014 Barry Murphy Msc Y
2018 Clara Sanz Nogues Msc Y
2013 Sarah Bulman PhD
2013 Janice O¿Sullivan PhD
2009 Nicole Scully Msc Y
2011 Rosanne Raftery MASTERS OF SCIENCE Y
2015 Gillian Sexton Msc Y
2015 Aine Fleming Msc Y
2012 Sinead D¿Arcy PhD
2008 Wondimagegnehu Mulatu Msc Y
2013 Paul Loftus MASTERS OF SCIENCE Y
2012 Dave McCarthy Msc Y
2009 Claire Kavanagh PhD

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2016/2017 Introduction to Medicine OMB3 Bone biology, Cartilage biology, Applied anatomy
2013-2015 Scientific Writing BES519 Clinical application of GDF-5 in bone repair: A review
2016/2017 Functional Anatomy and Biomechanics PO203 Applied Anatomy: Repair of Cartilage and Bone
2016/2017 Regenerative Medicine REM504 Developmental Biology, Applying developmental concepts to regenerative medicine
2016/2017 Pharmacology Research Project PM425 Investigating the effects of Growth Differentiation Factor-5 on chondrogenesis in fracture repair in non-diabetic stromal cells and diabetic stromal cells.
2016/2017 Transnational Medicine REM502 Regulatory oversight
2008-2017 Regenerative Medicine Research Project REM505 Changes annually
2016/2017 Surgical Lab Skills MD560 Pre-clinical assessment of a cell based product.

Internal Collaborators

  Name Description of Collaboration
Linda Howard
Co-investigation on HRB-Diabetes Ireland grant investigating the aetiology of diabetes-induced osteoporosis.
Sharon Glynn
Pilot study: Investigating the Impact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish Patients
Timothy O'Brien
Co-investigation on HRB-Diabetes Ireland grant investigating the aetiology of diabetes-induced osteoporosis.

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Helen Burke Galway University Hospitals IRELAND
Investigating Patient Perceptions of Diabetes-Induced Osteopathy
Colin Murphy Galway University Hospitals IRELAND
Pilot study: Investigating the Impact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish Patients
Declan Clarke Zoan Biomed IRELAND
Investigating the efficacy of coral as a bone void filler
John Carey Galway University Hospitals IRELAND